In the following sections, we’ll outline complementary approaches that may help your rheumatoid arthritis. If you have rheumatoid arthritis, the below strategies are not meant to replace your standard medical treatment. Make sure to consult with your doctor before making any significant changes to your day-to-day routine.
An observational study of 296 people found that 88% of smokers tested positive for rheumatoid factor over a period of 10 years. Also, the rheumatoid factor-positive group of people contained more smokers than the rheumatoid factor-negative group .
The risk of high rheumatoid factor levels was 4 times higher in current smokers than in people who never smoked, according to an observational study of 7,124 people. In another study of 100 people with rheumatoid arthritis (RA), rheumatoid factors were more than twice as high in current and former smokers than in people who never smoked [4, 5].
Smoking the equivalent of 1 pack (20 cigarettes) a day for 25 years was linked to a 3-fold increase in the risk of elevated rheumatoid factor in a study of 336 RA patients. What’s more, rheumatoid factor levels were directly linked to the number of years smoked in two studies of 673 people with RA [6, 7, 2].
Aquatic exercise describes any type of physical activity that takes place either partially or fully submerged in water. These activities can allow people to maintain physical fitness and reap the benefits of exercise even when they are not fully mobile out of the water .
In a review of 352 patients, researchers concluded that massage therapy could moderately reduce pain and increase function in joints affected by rheumatoid arthritis .
Massage therapy applying moderate pressure to tissues in the upper limbs was more effective than a light-pressure massage technique .
As part of a broader physical therapy regimen, massage is used to improve flexibility and function in arthritic joints .
There is contradictory evidence about the effectiveness of acupuncture for rheumatoid arthritis. One study found no benefit for pain and tenderness in the joints; another study found improvements in reported pain, grip strength, and arm strength after four weeks of acupuncture [17, 18].
Moxibustion, another form of acupuncture, applies small pieces of burning dried mugwort (a flowering plant) to acupuncture points. One meta-analysis found that moxibustion reduced pain and markers of inflammation in 281 subjects; however, other reviews have found no significant benefit [19, 20, 21].
A study of nurses found that those with greater exposure to UVB rays from the sun had the lowest rates of rheumatoid arthritis. Another study found that people who live further from the equator (who are likely to be exposed to less sunlight on average) are more likely to develop rheumatoid arthritis [23, 24].
According to multiple studies, people with a higher intake of vitamin D appear less likely to develop rheumatoid arthritis. However, there are conflicting reports on whether supplementing with vitamin D can improve pain in existing rheumatoid arthritis cases [25, 26, 27].
Tai chi may be a good form of exercise for people with chronic pain from rheumatoid arthritis. One clinical study found that rheumatoid arthritis patients who practiced tai chi reported less pain and better quality of life .
Whole body cryotherapy (WBC) involves immersing the body in a cold chamber, which emits vapors at extremely low temperatures ranging from -110℃ to -160 ℃ (around -160℉ to -220℉). This is usually done for an interval of 2 to 4 minutes [29, 30].
- Pain reduction
- Disease activity
Cryo chamber treatment reduced pain and the need for medication in 50 patients with different forms of arthritis. Additionally, well-being and mobility of the patients improved .
WBC significantly reduced pain and disease activity in two studies of 70 patients with various rheumatic disorders. Patients also had higher functionality in their joints and pain reduction lasting up to 2 months (especially in women) [35, 36].
The Mediterranean diet is a popular anti-inflammatory diet that may reduce swelling and pain in arthritic joints .
According to one study of 51 patients, those eating a Mediterranean diet had significantly higher vitality scores (a measurement of energy, quality of life, and general function) than those eating a typical western diet .
The anti-inflammatory effect of the Mediterranean diet may be due to its high content of olive oil. In fact, people whose diets include a lot of olive oil are significantly less likely to develop rheumatoid arthritis than those who use other types of cooking oils [38, 39].
Studies suggest that increased dietary intake of omega-3 fatty acids may protect against rheumatoid arthritis. In a meta-analysis of 20 clinical trials, higher omega-3 consumption improved rheumatoid arthritis symptoms and lab markers [40, 41].
Good dietary omega-3 sources include :
In a study of 53 rheumatoid arthritis patients, a vegetarian diet improved the severity of all measured symptoms and lab results after a year. However, some patients appeared to benefit a great deal from the diet change, while others did not benefit at all .
In a study of 70 women with rheumatoid arthritis, those who consumed supplementary garlic had improved antioxidant status, pain scores, and general quality of life compared to those who were given a placebo. The effects were apparent at doses of 500 mg of garlic per day, which could be achieved through diet or supplements .
In a small, open-label study, rheumatoid arthritis patients who drank a concentrated pomegranate juice extract once a day had improved inflammation and oxidative stress markers after twelve weeks. However, this study only had eight participants and no control group, so more research is needed to explore these effects .
In rat models of rheumatoid arthritis, pomegranate rind extract reduced pain and swelling. These effects were attributed to decreases in the activity of inflammatory markers, including NF-kB .
In one study of 250 patients, fish oil was as effective as ibuprofen in reducing pain caused by arthritis .
Borage and black currant oil, two oils rich in gamma linolenic acid (GLA), reduced joint inflammation, pain, and stiffness in 4 trials on almost 150 people with rheumatoid arthritis, but low doses of evening primrose oil were ineffective in 2 trials on 58 people [52, 53, 54, 55, 56, 57].
GLA (from borage and evening primrose oil), fish oil (rich in EPA), and their combination reduced rheumatoid arthritis symptoms, painkiller use, and the risk of heart disease in 4 trials on almost 400 people [58, 59, 60, 61].
A meta-analysis concluded that GLA may reduce pain and disability in people suffering from rheumatoid arthritis .
Borage is a flowering herb whose oil is especially rich in the omega-6 PUFA gamma-linolenic acid.
In 2 clinical trials, thunder god vine (Tripterygium wilfordii) extract (60-360 mg/day) improved joint inflammation and pain from rheumatoid arthritis. It was more effective than the anti-rheumatic drug sulfasalazine in another trial on 62 people [67, 68, 69].
Similarly, its tincture applied on the skin improved rheumatoid arthritis in a trial on 61 people .
Curcumin, an active compound found in the yellow spice turmeric, reduced some symptoms of rheumatoid arthritis in multiple studies. At high doses, it improved pain, morning stiffness, joint inflammation, and mobility [83, 84, 85].
However, curcumin does not appear to be effective at lower doses. In the available studies, patients only benefited when consuming at least 500 mg per day .
In 51 patients, 3-month treatment with glucosamine notably improved RA symptoms .
On the other hand, a combination of glucosamine, chondroitin, and quercetin had no effect on 22 RA patients .
In a clinical trial on 40 rheumatoid arthritis patients, cat’s claw combined with conventional treatments (sulfasalazine/hydroxychloroquine) reduced tender and painful joints .
In a small study of 58 rheumatoid arthritis patients, a cannabis extract containing both CBD and THC significantly reduced pain and increased quality of sleep. Some research suggests that the combination of CBD and THC is more effective than CBD alone; however, CBD oil is much more readily available and considered non-psychoactive .
In mice with this condition, oral and injected CBD relieved inflammation and slowed the joint damage progression. CBD also prevented T cells and joint cells (synoviocytes) from reproducing and releasing pro-inflammatory cytokines (TNF-alpha and IFN-gamma) .
Similarly, a topical CBD gel reduced joint swelling, pain, and the levels of inflammatory markers (such as TNF-alpha) in the nerves of rats with rheumatoid arthritis .
Two studies in humans and dogs found that animals with rheumatoid arthritis or osteoarthritis had higher levels of both CB receptors and several cannabinoids in the joints. This suggests that the body activates the endocannabinoid system to fight arthritis. In line with this, increasing cannabinoids may be a good therapeutic strategy [108, 109].
Superoxide dismutase treatments reduced the pain associated with osteoarthritis and rheumatoid arthritis in a handful of studies. However, in all of these, superoxide dismutase was administered as an injection into the problem joints; there is no data supporting the use of superoxide dismutase as a supplement for arthritis [112, 113, 114, 115].
In a study of 45 rheumatoid arthritis patients, supplementing with Bacillus coagulans probiotics decreased overall pain, but not the number of painful or swollen joints, after 60 days. In this group, B. coagulans improved pain, improved self-assessed disability, reduced CRP levels, and improved the ability to walk 2 miles, reach, and participate in daily activities .
Mangiferin has shown promise in cell studies for reducing the type of inflammation that causes rheumatoid arthritis. According to one study, mangiferin may prevent the destruction of joint tissues by promoting cell death in certain destructive immune cells [118, 119].
In a small randomized controlled trial, a standard rheumatoid arthritis medication combined with mango stem bark extract reduced disease activity and symptoms after a year of supplementation. However, the effects on disease activity were similar to that of the medication alone .
It may not be feasible to get the mangiferin needed by eating mangoes. However, mango leaf extract is available as a supplement.
These arthritis-relieving properties may be due to nettle’s ability to block a protein called NF-κB, which would otherwise increase the production of inflammatory compounds. NF-κB is often overactive in people with arthritis [122, 123].
Stinging nettle is often used by traditional practitioners to improve arthritis symptoms. Urtication, also known as ‘flogging with nettles,’ is a technique where users apply raw, unprocessed stinging nettle leaves or stems to the body to generate inflammation. This has been used since Ancient Roman times for relieving chronic rheumatism, but researchers have only just begun to investigate its effectiveness .
Ashwagandha reduced pain, stiffness, and disability in 60 people with knee joint pain. Ayurvedic treatment containing ashwagandha reduced pain, joint tenderness, and swelling in a study of 86 people with rheumatoid arthritis [125, 126].
Note that vitamin K1 (phytonadione) did not have the same benefit .
In a meta-analysis of 260 patients with rheumatoid arthritis, 400 mg of Boswellia serrata (Indian frankincense) extract reduced swelling, pain, and stiffness. Patients were also able to reduce painkiller intake and required fewer emergency treatments .
Note that boswellic acids may only become detectable in the blood when administered with a high-fat meal .
In a study of 70 rheumatoid arthritis patients, taking 1500 mg of ginger powder per day led to significantly reduced disease markers after 12 weeks. The authors suggested that the benefit might come from alterations in gene expression: the group taking ginger supplements had increased levels of FOXP3 and decreased RORC expression .
Rheumatoid arthritis patients who supplemented with blackcurrant seed oil for 24 weeks experienced a reduction in disease symptoms. However, a very large dose (15 capsules daily) was required to see a benefit .
In rats with arthritis, the active ingredient, thymoquinone lowered numerous pro-inflammatory cytokines (including IL-6, IL-1β, TNF alpha, all Th1 cytokines) while increasing anti-inflammatory ones (IL-10) .
Conjugated linoleic acids (CLA) are poly-unsaturated fatty acids found primarily in meat and dairy products, but also available in supplement form.
In a study of 87 patients, three months of CLA supplementation resulted in reduced pain and stiffness compared to the control group. Researchers concluded that CLA may be useful in addition to conventional rheumatoid arthritis therapies .
Quercetin supplements (500 mg/day) had no effect on some inflammatory markers (CRP) but did reduce others (TNF-alpha and IL-6) in an 8-week study of 51 women. But in a later 8-week follow up study in 50 women, the same dose did reduce joint stiffness, morning pain, after-activity pain and the inflammatory marker TNF-alpha [139, 140].
In a cellular study, Quercetin triggered the death of inflammatory joint cells that contribute to the development of rheumatoid arthritis. In another study, it also stopped these cells from dividing and prevented neutrophil activation, which worsens the autoimmune response [141, 142].
In a study of 100 rheumatoid arthritis patients, 1 g of resveratrol per day significantly improved swelling, tenderness, and disease activity scores and decreased lab markers of inflammation and disease severity. The authors suggested that resveratrol could make a good addition to conventional treatment plans .
However, selenium may or may not help people with existing cases of rheumatoid arthritis. In one study, 3 months of selenium supplementation improved joint swelling, tenderness, and mobility, but other studies found no benefit [145, 146].
Sesamin is an active compound found in sesame, camphor, and other plants. In a study of 44 rheumatoid arthritis patients, sesamin supplements reduced joint pain and tenderness and improved lab markers of inflammation [147, 148].
Bromelain is an enzyme found in pineapples. In 77 patients with rheumatoid arthritis or osteoarthritis, bromelain (400 mg) improved overall symptoms, reduced stiffness, and improved physical function .
In one study of 374 patients with rheumatoid arthritis and coronary artery disease (which frequently occur together), 500 mg of baicalin per day significantly reduced blood lipids and markers of inflammation .
Horsetail improved symptoms and regulated the immune response in most cases in a study of 60 patients with rheumatoid arthritis. It increased IL-10 and decreased TNF-alpha, which may make it a good add-on to conventional therapies .
Giant horsetail extract reduced pain, inflammation, and autoimmune response in a mouse model of rheumatoid arthritis and osteoarthritis. The medicinal benefits of the compounds in horsetail are promising, but more research is needed .
In another trial on 30 people with this condition, cod liver oil (five 300 mg capsules, 2x/day) reduced the use of arthritis medications (Diclofenac Sodium) and had fewer side effects .
In a follow-up study of 58 patients with rheumatoid arthritis, 10 g cod liver oil (with 2.2 g of omega 3s) over 9 months reduced the use of painkillers (diclofenac, naproxen, and ibuprofen) .
In 60 patients with severe rheumatoid arthritis, three months of chicken type II collagen reduced the number of swollen and tender joints compared to placebo (DB-RCT). Four patients in the collagen group saw all symptoms disappear and a halt in the progression of the disease .
A larger study of 274 rheumatoid arthritis patients found that a range of doses (20, 100, 500, and 2,500 μg) reduced swollen and tender joint counts .
Zinc is available in supplement form, and the richest dietary sources are oysters, other seafood, and beef .
Before taking sweet wormwood (artemisia annua), discuss this supplement with your doctor.
Sweet wormwood is an herb used in traditional Chinese medicine. Due to its potent antiviral and anti-inflammatory properties, a compound of sweet wormwood (artemisinin) and its derivative drugs have been recommended by the World Health Organization as treatments for malaria .
Artemisinin and its derivatives were reported to suppress the release of inflammatory proteins from joint cells of rheumatoid arthritis patients .
In a randomized controlled trial, a combination of standard rheumatoid arthritis drugs and a sweet wormwood extract was more effective at reducing joint swelling, pain, and tenderness than standard drugs alone .
To avoid adverse effects and unexpected interactions, only use sweet wormwood as directed by a medical professional.